In a statement released yesterday, Christina Applegate announced she was leaving the NBC show Up All Night over creative differences. Will Arnett and Maya Rudolph are staying. The show is not what it started out to be and is going to be dramatically different if it ever gets back on the air, but it is tough to walk away from a network sitcom if there is any chance it will stay on the air. It is not like Christina has had a run of success when she has been given shows so you would think she would have hung on until the bitter end. Will and Christina have had some up and down moments during the run of the show and their relationship is not as warm as it used to be. It is interesting to note that while she specifically thanked Lorne Michaels in her statement, she did not mention any of the cast specifically and just threw them in the same sentence as cast, producers and crew.